Syntheses of Gramicidin S Analogs Containing δ-Aminovaleric Acid. [5–1′-δ-Aminovaleric Acid]-Gramicidin S and [5–1′, 5′-1-Bis(δ-Aminovaleric Acid)]-Gramicidin S
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منابع مشابه
Gramicidin S; the sequence of the amino-acid residues.
Consden, R., Gordon, A. H. & Martin, A. J. P. (1944). Biochem. J. 38, 224. Consden, R., Gordon, A. H. & Martin, A. J. P. (1945). Biochem. J. 39, xlvi. Consden, R., Gordon, A. H. & Martin, A. J. P. (1946a). Biochem. J. 40, 33. Consden, R., Gordon, A. H. & Martin, A. J. P. (1946b). Biochem. J. 40, 580. Consden, R., Gordon, A. H., Martin, A. J. P. & Synge, R. L. M. (1947). Biochem. J. 41, 596. Mar...
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Gramicidin S (GS) is a cyclic cationic antimicrobial peptide (CAP) with a wide spectrum of antibiotic activities whose usage has been limited to topical applications owing to its cytotoxic side effects. We have synthesized tetrahydrofuran amino acid (Taa)-containing GS analogues, and we have carried out conformational analysis and explored their structure activity relationships by evaluating th...
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tions with C2 symmetry and results in disruption of its cell membrane.1-9,13) In addition, no resistance has been found for the antibiotics, because it requires significant alteration of the lipid composition of the cell membrane.14) In view of the fact that widespread antibiotic resistance has become a serious threat to public health15-18), these amphiphilic antibiotics are attractive targets ...
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Several amino acids are known to affect the gramicidin S producer Bacillus brevis ATCC 9999 with respect ot growth, soluble gramicidin S synthetase formation, antibiotic production, or a combination of these. Our studies confirmed that arginine has paradoxical effects on the B. brevis fermentation; it markedly increased growth and antibiotic production, yet decreased the soluble heavy gramicidi...
متن کاملThe free amino group of gramicidin S.
on the other hand, maintain that both amino and carboxyl groups are present and that the 8-amino group of the ornithine residue is not free. Their evidence for this latter point, nevertheless, is not very convincing and the problem was clearly one which could be readily settled by applying the new dinitrofluorobenzene (DNFB) method (Sanger, 1945). Accordingly at Dr Synge's suggestion, the prese...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1977
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.50.2143